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Rintaro Okabe is a self-proclaimed "mad scientist" who believes that an international scientific organization named SERN is conspiring to reshape the world according to its own interests. He and his friend Itaru Hashida inadvertently create a gadget able to send messages to the past.

About one thousand years into the future, civilization has been retrograded and humans are living dispersed within small communities. People in this era have a psychic power called "Juryoku" which materializes things they imagine.

The series is set on a fictional medieval island where humans are plagued by Yoma (妖魔), humanoid shape-shifters that feed on humans. A mysterious group, known as The Organization, creates human-Yoma hybrids to kill Yoma for a fee.