Haruhi Fujioka is searching for nothing more than a quiet place to study in the most elite high school academy in all of Japan when she stumbles across the mysterious third music room. Inside she encounters six beautiful men, the members of the host club.

Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

Cross Academy is different from any other school. It has a Day Class and a Night Class, with different uniforms and no interaction between these two classes.

The curse of an evil witch turns a plain young hat-maker, Sophie, into an old woman. Sophie runs away to confront the witch and become young again when she rescues a trapped animated scarecrow.

While fighting to save his village from the attack of a demon-god Ashitaka comes in contact with it and is inflicted with a deadly curse. In his search for a cure he is forced to leave his village forever and journey to the forest inhabited by animal gods.

Set on the fictional year of 2010, the world has been split into 3 superpowers: The Holy Britannian Empire (the Americas; also called Britannia), the Chinese Federation (Asia), and the European Union (Europe and Africa; previously known as the Euro-Universe. Also known as Europa United in Akito the Exiled).

The story follows a college sophomore named Keiichi Morisato, who accidentally dials the Goddess Help Hotline, an agency that grants the wishes of humans. The goddess Belldandy appears before him, and says that she has been sent to fulfill a single wish.