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Gatts, an incredibly powerful warrior, is a lone swordsman in a medieval-type fantasy world. He loses in a battle with a mysterious swordsman named Griffith, who holds a pendant called the Eye of God.

Hellsing, a secret organization within the British government, has long been battling supernatural threats to keep people safe from creatures of the night. They have a secret weapon in the form of an incredibly powerful vampire Alucard.

Alucard is not just any immortal, but probably one of the oldest and strongest beings known to exist. This vampire, however, is duty bound to the Hellsing family, who acts as the dogs of England's queen, protecting the country from the most dangerous parts of the underground, namely other vampires.

A girl named Rachel wakes up in an unknown place with no memory of how she got there or what her life was. She starts to explore the area and ends of finding a bunch of psychopathic people that each have their own floor in the building that their in.