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Yamato, Naruto Uzumaki, Sakura Haruno, and Sai are assigned on a mission to capture Mukade, a missing-nin. They all have chakra-knives, which are uniquely-designed trench knives that allow a ninja to infuse their chakra with it to produce an added effect.

In a world where Japan has a "National Welfare Act", which ensures that during vaccinations in first grade, 1 out of every 1000 children will be, unknowingly, injected with a nanomachine that will detonate in their heart between the ages of 18 and 24, so the people in the country will value life more. The plot revolves around Kengo Fujimoto, a man whose job is to deliver "Ikigamis" to the house of those scheduled to die.