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Komatsu Nana moves to Tokyo, following after her boyfriend Shouji to gain a life she has always dreamed of. The anime is about two girls named Nana, who are very different.

After the unsustainable growth of the human population on Earth, the United Nations has opted to colonize Mars. During this expedition, the humans discovered two alien technologies: The Bacillus virus and the Crusnik nanomachines.

Cross Academy is different from any other school. It has a Day Class and a Night Class, with different uniforms and no interaction between these two classes.

The curse of an evil witch turns a plain young hat-maker, Sophie, into an old woman. Sophie runs away to confront the witch and become young again when she rescues a trapped animated scarecrow.

The story of Death Note revolves around a high school student called Yagami Light. His life changed when he saw a supernatural notebook that fell from the sky.

Aliens, Espers, and Time Travelers collide around a young girl with the most ultimate power. The Melancholy of Haruhi Suzumiya is about a girl known as Haruhi and a boy she meets in school.

They say that you'll never know what a person's real character is until you've started living with him/her/ them under one roof. Well, it definitely is true in the case of a 16 year old female protagonist, Tohru Honda from the series, Fruits Basket.

On his first day at his new school, twelve-year-old Ritsuka Aoyagi meets a mysterious twenty-year-old male named Soubi Agatsuma. Soubi claims to be a good friend of Ritsuka's brother, Seimei, who was murdered when Ritsuka was ten years old.

Known for its Space Western theme, Trigun is about a man named "Vash the Stampede" and the two Bernardelli Insurance Society employees who follow him around in order to minimize the damages inevitably caused by his appearance. Most of the damage attributed to Vash is actually caused by bounty hunters in pursuit of the "60,000,000,000$$" (sixty billion "double dollars") bounty on Vash's head for the destruction of the city of July.

A young sorceress, Lucy Heartfilia, travels to the land of Fiore to join the magical Fairy Tail Guild. Along the way, she meets Natsu Dragneel, a teenage boy looking for a dragon named Igneel.

There once was a man named Gold Rodger, a pirate, and he was given the glorious title: ‘King of the Pirates’ for possessing the legendary treasure, One Piece. He had fame, fortune, and power, until one day, he caught and brought to the execution tower to be executed.

Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

Lucky Star follows the hilarious and mischievous daily lives of four young girls as they move through high school. h2.