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Mutated homo sapiens that have a dangerous telekinetic power is being captured and isolated in laboratories by the government. One of the sixth-sense-possessing humanoids escapes loses her memories and winds up living with a boy from her past.

Failure Human Tsukune is unexpectedly put into a school for monsters, where he meets the cute vampire Moka. He later meets succubus, Kurumu, a young witch genius, Yukari, an ice girl, Mizore, and Ruby a second older Witch Adept, Ruby.

After living with his father and learning martial arts in the mountains for 17 long years, Yoichi Karasuma is sent to a hectic city-life under his father’s orders. He is received by the Ikaruga household -- also a martial arts family -- which practices the Ukiha Divine Wind Style Swordplay.

Everyone is born with the ability to use magic in the world of Maburaho and is thus labeled magicians. However, the magical prowess of each person is not equal.

Hayate Ayasaki is an unfortunate young boy whose parents have a serious gambling addiction. Despite working really hard and trying to make ends meet, Hayate was abandoned by his parents and left him an overwhelming 150 million yen of debt to the Yakuza.

Kinjirō Sakamachi has gynophobia (fear of women), due to his violent mother and sister. Subaru Konoe is the butler of his classmate, Kanade Suzutsuki, and has to dress as a male due to butlers having to be men.