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Edward Elric makes a fatal mistake that drags his brother and his own body into an abyss, and they must seek the philosopher's stone to return their bodies to normal. They learn more and more about alchemy along the way during their adventures.

Fullmetal Alchemist: Brotherhood, commonly referred to as FMAB is the second adaptation of the hit manga series Fullmetal Alchemist by Hiromu Arakawa. In 2003, shortly after the manga began its run, the first adaptation titled Fullmetal Alchemist was made.

Shibusen, standing for Death Weapon Meister Academy (DWMA) the technical school for Reaper Armsmasters that operates from the deepest recesses of all the corners of the world, in order to prevent the second coming of the so-called Demon God who is feared upon bringing destruction of all humankind and envelop the world with nothing but madness and darkness. The reaper built this agency for weapons and for those who will be trained to wield them.

A young sorceress, Lucy Heartfilia, travels to the land of Fiore to join the magical Fairy Tail Guild. Along the way, she meets Natsu Dragneel, a teenage boy looking for a dragon named Igneel.