Set in the future, the plot follows Zoichi Kanoe and his AI companion Fuyu Kanoe, whose luminous form is integrated into the system of his motorcycle. They are agents sent by TOA Heavy Industries to retrieve humans with the ability to resist and transmute the N5S infection, which is spreading across the world, turning humans into “Drones”; disfigured, zombie-like beings.
The art in Biomega is similar to Blame!, with its complicated concrete sprawl and extremely vast, empty spaces. In this manga, there is emphasis on the swiftness of the attacks made by Zoichi, such as the gun being holstered just before the enemies fall to the ground. Speed is crucial in this manga, unlike in Blame!, and the plot develops quickly.